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Prior Suggestive Symptoms in One-Third of Patients Consulting for a "First" Demyelinating Event JNNP 82:323-325, Gout,O.,et al, 2011 See this aricle in Pubmed Article Abstract A patient-administered questionnaire subsequently validated by the neurologist demonstrated that 33% of patients consulting for a first Demyelinating event had prior symptoms suggestive of central nervous system demyelination that had gone unnoticed, and almost 70% had either sequelae of prior demyelination or McDonald criteria for dissemination in space. Such a questionnaire could be a useful tool for earlier diagnosis of multiple sclerosis.

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